Description
Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation (PubMed: 26424569, PubMed: 32972995). Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed: 8181059, PubMed: 7665574, PubMed: 7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed: 7759950)